Neuroinflammation plays a critical role in neurologic and psychiatric disorders of the central nervous system (CNS) from ischemic stroke and traumatic brain injury to Alzheimer’s disease, schizophrenia, and major depression. The application of multi-compartment diffusion MRI techniques for the robust, non-invasive, and quantitative evaluation of microglial morphology and density in the setting of acute and chronic neuroinflammation would represent an important advancement in understanding, identification, and therapeutic monitoring of microglia across a broad spectrum of acute and chronic disorders of the CNS. We present the first evidence and application of multi-compartment diffusion MR techniques for the sensitive detection of changes in microglial density throughout the brain.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords