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Abstract #3225

Optimized quantification of T2 relaxation times using gel phantoms in animal models for high-consequence pathogens in a Biosafety Level 4 environment

Marcelo Adrián Castro1, Ji Hyun Lee1, Joseph Laux1, Harry Friel2, Jeffrey Solomon3, David Thomasson1, and Dima Hammoud4

1National Institute of Allergy and Infectious Diseases - Integrated Research Facility, National Institutes of Health, Fort Detrick, MD, United States, 2Philips Healthcare, Highland Height, OH, United States, 3Clinical Monitory Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, National Institutes of Health, Frederick, MD, United States, 4Clinical Center, National Institutes of Health, Bethesda, MD, United States

This experiment improved the accuracy of in vivo T2 measures used to evaluate blood brain barrier (BBB) disruption and subtle cerebral edema in non-human primate models of high-consequence viral infections in a Bio-Safety Level 4 (BSL-4) environment. In a healthy non-human primate, we used four gel phantoms to optimize T2 relaxation times and investigated dependence of T2 on echo times. This methodology improved the accuracy of T2 estimation using fast spin echo sequences and phantoms. We hypothesized that reliable T2 values can be obtained by adding a phantom-calibration step to the T2 map calculation.

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