Abstract #3225

Optimized quantification of T2 relaxation times using gel phantoms in animal models for high-consequence pathogens in a Biosafety Level 4 environment

Marcelo Adrián Castro¹, Ji Hyun Lee¹, Joseph Laux¹, Harry Friel², Jeffrey Solomon³, David Thomasson¹, and Dima Hammoud⁴

¹National Institute of Allergy and Infectious Diseases - Integrated Research Facility, National Institutes of Health, Fort Detrick, MD, United States, ²Philips Healthcare, Highland Height, OH, United States, ³Clinical Monitory Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, National Institutes of Health, Frederick, MD, United States, ⁴Clinical Center, National Institutes of Health, Bethesda, MD, United States

This experiment improved the accuracy of in vivo T₂ measures used to evaluate blood brain barrier (BBB) disruption and subtle cerebral edema in non-human primate models of high-consequence viral infections in a Bio-Safety Level 4 (BSL-4) environment. In a healthy non-human primate, we used four gel phantoms to optimize T₂ relaxation times and investigated dependence of T₂ on echo times. This methodology improved the accuracy of T₂ estimation using fast spin echo sequences and phantoms. We hypothesized that reliable T₂ values can be obtained by adding a phantom-calibration step to the T₂ map calculation.

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