Meeting Banner
Abstract #3226

Neuroimaging of Nipah Virus infection in an African Green Monkey Model

Ji Hyun Lee1, Yu Cong1, Joseph Laux1, Marcelo Castro1, Matthew Lackemeyer1, Jordan Bohannon1, Oscar Rojas1, Jeffery M. Solomon2, Irwin M. Feuerstein1, Vincent Munster3, Dima A. Hammoud4, and Michael R. Holbrook1

1IRF, NIAID/NIH, Frederick, MD, United States, 2Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, NCI Campus, Frederick, MD, United States, 3Virus Ecology Unit, Laboratory of Virology, Rocky, Mountain Laboratories, NIAID/NIH, Hamilton, MT, United States, 4Clinical Center, NIH, Bethesda, MD, United States

The purpose of this study was to utilize MRI to assess alterations in the brain that occur in African Green Monkeys infected with Nipah virus (NiV) via aerosol inoculation. Within 15 days of exposure to NiV, signal alterations were observed in the brain in T2-weighted, fluid-attenuated inversion recovery, and diffusion-weighted images, suggestive of infarction, inflammation and edema induced by NiV. The identification of non-invasive imaging biomarkers of acute NiV neurologic disease progression in this animal model could aid in the examination of potential vaccines and therapeutics.

This abstract and the presentation materials are available to members only; a login is required.

Join Here