Abstract #3237

Development of a Swine Model to Evaluate Radiation-Induced Brain Injury: A Preliminary Report

Whitney D. Perez¹, Ilektra Athanasiadi², David A. Edmondson¹, Jeannie Plantenga^2,3, and Carlos J. Perez-Torres^1,3

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, United States, ³Center for Cancer Research, Purdue University, West Lafayette, IN, United States

Radiation-induced brain injury (RIBI) is an irreversible and progressive long-term effect of radiation therapy. Current pre-clinical experiments use mouse models, which do not accurately replicate the pathology as seen in humans. We chose to simulate RIBI within a swine model because its brain structures are more comparable to human brain structures. Our preliminary findings show similar resemblances to the pathologies seen in human patients affected by RIBI.

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