Abstract #3238

Postnatal Ocular Development in Normal and Visually Impaired Rats using in vivo Multi-Modal MRI

Malack Hamade¹, Hassan Hamade¹, Swarupa Kancherla², and Kevin C. Chan^1,3

¹Department of Ophthalmology, New York University School of Medicine, New York, NY, United States, ²Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, ³Department of Radiology, New York University School of Medicine, New York, NY, United States

Ocular development is a complex process yet limited tools are currently available for non-invasive and longitudinal studies of the whole eye while minimizing biovariability. Using 7-Tesla MRI, we showed the growth characteristics of the anterior chamber and posterior chamber, the lens and the vitreous humor of rats from postnatal day 1 to 60 and compared the development of these three compartments between normal and impaired states. We conclude that MRI is an effective tool in characterizing normal and abnormal postnatal ocular growth over time before and after eyelid opening.

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