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Abstract #3245

Diffusion Metrics of White Matter in Cerebral Small Vessel Disease: Unravelling the Variance in Microstructural Integrity

Elene Iordanishvili1, Ezequiel Farrher1, Melissa Schall1, Ana-Maria Oros-Peusquens1, Ketevan Kotetishvili2, Farida Grinberg1, and Jon Shah1,3,4

1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, 2Georgian Technical University, Tbilisi, Georgia, 3Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Jülich, Germany, 4JARA - BRAIN -Translational Medicine, Aachen, Germany. Department of Neurology, RWTH Aachen University, Aachen, Germany

Cerebral small vessel disease (SVD) has a long period of silent progression until it clinically manifests as a stroke or cognitive decline. Early detection of microstructural alterations in the white matter will help to develop targeted therapy and avoid clinical consequences. The need for advanced imaging to reflect the plethora of the changes is increasing. Here, we used the methods for the analysis of the diffusion MRI signal to investigate microstructural alterations in SVD. Our study identified the most frequently changed parameters and the affected regions. We also show increased changes in the diffusion MRI metrics, corresponding with disease severity.

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