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Abstract #3246

Hemodynamic impairments in asymptomatic unilateral carotid artery stenosis are increased within individual watershed areas

Stephan Kaczmarz1,2, Jens Goettler1,2,3, Jan Petr4, Mikkel Bo Hansen5, Jan Kufer1, Andreas Hock6, Christian Sorg1, Claus Zimmer1, Kim Mouridsen5, Fahmeed Hyder2, and Christine Preibisch1,7

1Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2MRRC, Yale University, New Haven, CT, United States, 3Clinic for Radiology, Technical University of Munich, Munich, Germany, 4PET center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 5Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark, 6Philips Healthcare, Hamburg, Germany, 7Clinic for Neurology, Technical University of Munich, Munich, Germany

Internal carotid-artery stenosis (ICAS) causes complex and not yet well understood physiological impairments, which currently limits treatment decisions. We present multimodal perfusion and oxygenation-related MRI-data from unilateral asymptomatic ICAS-patients and age-matched healthy controls. The major aim was to investigate hemodynamic impairments in ICAS within individually defined watershed areas (iWSA’s) to account for individual vascular configurations. We found statistically significant lateralization of hemodynamic parameters within iWSA’s - strongest in WM of iWSA’s. Therefore, our iWSA-based approach facilitates detection of even subtle hemodynamic changes in ICAS. Furthermore, we detected spatially widespread capillary flow heterogeneity increases which are promising future treatment indicators.

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