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Abstract #3249

Robust MRI assessment of cerebral microvasculature using stimulated-echo diffusion-imaging method

DongKyu Lee1 and HyungJoon Cho1

1Bio-medical engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of

Stimulated-echo diffusion-imaging method was employed to reduce the effect of macroscopic field inhomogeneity and large vessel overestimation on the quantification of blood volume fraction and mean vessel radius. Stimulated-echo diffusion-imaging method were compared with conventional spin-echo and gradient-echo methods by Monte Carlo (MC) proton diffusion simulations and in vivo rat experiments on a 7 T system. The results of this study showed that stimulated-echo based MR relaxation-rates, ∆RSTE,long TD (ΔR2* like) and ∆RSTE,short TD (ΔR2 like), provide the robust means of assessing cerebral microvasculature where the macroscopic field inhomogeneity is severe and signal contamination from adjacent large vessel is significant without necessity of co-registering gradient- and spin-echo images.

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