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Abstract #3267

The Cerebral Blood Flow Changes of Executive Dysfunction in Parkinson’s Disease Measured by Arterial Spin Labeling MRI at Cerebral Cortex Parcellations Obtained from Resting State fMRI

Dilek Betul Arslan1, Sevim Cengiz1, Ani Kicik2, Emel Erdogdu2,3, Zerrin Yildirim4, Zeynep Tufekcioglu4, Basar Bilgic4, Hasmet Hanagasi4, Aziz Mufit Ulug1, Tamer Demiralp2,5, Ibrahim Hakan Gurvit4, and Esin Ozturk-Isik1

1Biomedical Engineering Institute, Bogazici University, Istanbul, Turkey, 2Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, 3Institute of Psychology and Cognition Research, University of Bremen, Bremen, Germany, 4Department of Neurology, Istanbul University, Istanbul, Turkey, 5Department of Physiology, Istanbul University, Istanbul, Turkey

The aim of this study is to find cerebral blood flow (CBF) based biomarkers of executive dysfunction in Parkinson’s disease (PD) at cerebral cortex parcellations obtained from resting state fMRI. CBF maps of PD with mild cognitive impairment, cognitively normal PD and healthy controls were compared at brain regions based on parcellations obtained from resting state fMRI. Additionally, CBF values of the PD subjects were classified according to Stroop scores and COMT genotype. Hypoperfusion in several brain networks related with executive functioning was observed in PD patients with executive dysfunction, and also in patients with COMT Met/Met genotype.

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