Abstract #3267

The Cerebral Blood Flow Changes of Executive Dysfunction in Parkinson’s Disease Measured by Arterial Spin Labeling MRI at Cerebral Cortex Parcellations Obtained from Resting State fMRI

Dilek Betul Arslan¹, Sevim Cengiz¹, Ani Kicik², Emel Erdogdu^2,3, Zerrin Yildirim⁴, Zeynep Tufekcioglu⁴, Basar Bilgic⁴, Hasmet Hanagasi⁴, Aziz Mufit Ulug¹, Tamer Demiralp^2,5, Ibrahim Hakan Gurvit⁴, and Esin Ozturk-Isik¹

¹Biomedical Engineering Institute, Bogazici University, Istanbul, Turkey, ²Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, ³Institute of Psychology and Cognition Research, University of Bremen, Bremen, Germany, ⁴Department of Neurology, Istanbul University, Istanbul, Turkey, ⁵Department of Physiology, Istanbul University, Istanbul, Turkey

The aim of this study is to find cerebral blood flow (CBF) based biomarkers of executive dysfunction in Parkinson’s disease (PD) at cerebral cortex parcellations obtained from resting state fMRI. CBF maps of PD with mild cognitive impairment, cognitively normal PD and healthy controls were compared at brain regions based on parcellations obtained from resting state fMRI. Additionally, CBF values of the PD subjects were classified according to Stroop scores and COMT genotype. Hypoperfusion in several brain networks related with executive functioning was observed in PD patients with executive dysfunction, and also in patients with COMT Met/Met genotype.

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