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Abstract #3266

Frequency specific functional connectivity density in Parkinson’s disease: A resting-state fMRI study

Xue-hua Peng1, Jian-bo Shao1, Hui-jing Ma1, Zhiyao Tian1, Long Qian2, and Bai-qi Zhu1

1Department of Radiology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, wuhan, China, 2GE Healthcare, MR Research China, Beijing, China

The functional connectivity of the brain in Parkinson’s disease (PD) has been largely investigated focusing on a low frequency oscillation from 0.01 to 0.1 Hz. Nevertheless, the frequency specificities relating to the functional connectivity have not yet been fully understood. In this study, we utilized analysis of the functional connectivity density (FCD) to determine changes in patients with PD and in healthy controls in wo different frequency bands were analyzed. Our results demonstrated differential FCD maps from both spatial and frequency domain, thus providing a novel insight for investigation of the neuroimaging biomarkers in PD.

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