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Abstract #3269

A Framework for Integrating Diffusion and rs-fMRI with Measurements of Cognitive Function in the Rhesus Macaque Frontal Lobe and Striatum

Zheng Liu1,2, Alison R. Weiss1, Xiaojie Wang1,2, Jackie Domire1, William Liguore1, Christopher Kroenke1,2,3, and Jodi L. McBride1,3

1Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States, 2Advanced Image Research Center, Oregon Health and Science University, Portland, OR, United States, 3Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United States

Brain atlases commonly used for characterizing neurodegenerative processes are frequently referenced to a specific imaging modality. Here we describe a combined gray matter and white matter atlas to be used in the study of a rhesus macaque model of Huntington’s disease. We illustrate how this atlas will be used to integrate diffusion tensor imaging and resting-state functional MRI connectivity with measures of cognitive behavior. Prefrontal WM tracts, cortical and basal ganglia regions are labeled in the same space for characterization of WM microstructure changes and cognitive and motor loop connectivity. The results of preliminary study show that these MRI measurements can identify correlations with cognitive behavior measurements.

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