Abstract #3270

Change in fMRI activation between deep brain stimulation on and off states in patients with Parkinson’s disease during a stop-signal task

Pallab K Bhattacharyya^1,2, Adam Aron³, Jian Lin¹, Mark J Lowe¹, Anna Crawford¹, Andre Machado⁴, Mahsa Malekmohammadi⁵, Nader Pouratian⁵, and Stephen E Jones¹

¹Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ²Radiology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, United States, ³Psychology, University of San Diego, San Diego, CA, United States, ⁴Neurological Institute, Cleveland Clinic, Cleveland, OH, United States, ⁵Neurosurgery, University of California Los Angeles, Los Angeles, CA, United States

Motor regulation pertaining to stopping when necessary is impaired in Parkinson disease (PD) and is modulated by deep brain stimulation (DBS) therapy. We performed fMRI study at 3T using a stop-signal task with PD patients having implanted DBS, and investigated differences in activation in networks responsible for stopping between on and off states of DBS. Overall, larger and stronger activation was observed in this preliminary study when the DBS was turned on for go (when the subject is supposed to press button) minus baseline and successful stop (when the subject successfully stopped) minus go contrasts.

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