Abstract #3271

Neuroplasticity in patients with post surgical olfactory dysfunction after olfactory training, assessed with fMRI.

Francisco García-Huidobro¹, Cristian Montalba^2,3,4, Andrés Rosesbaum¹, Mariana Zurita⁵, David Jofré¹, Sergio Uribe^2,3,4, Marcelo Andia^2,3,4, Pablo Villanueva⁶, Claudio Callejas¹, Claudia González¹, and Cristian Montalba²

¹Otorhinolaryngology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, ²Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, ³Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁴Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile, ⁵Institute of Cognitive Neuroscience., University College London, London, UK., London, United Kingdom, ⁶Neurosurgery Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

We evaluated the effect of olfactory training in olfactory pathway brain areas in subjects with olfactory dysfunction after transsphenoidal surgery for pituitary tumors. For this purpose, we compare 2 groups of subjects, one with olfactory training, and a second without training. All of them underwent with an fMRI block designed with eucalyptus odor. An olfactory test were measured in all subjects. The subjects with olfactory training showed a clinical improvement and more activations of compensatory olfactory central brain areas, in comparison with subjects without olfactory training, that they did not show a clinical improvement and activated less compensatory olfactory areas.

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