We detected the alteration of white matter connectome in Parkinson’s disease (PD) patients with and without Rapid eye movement sleep behavior disorder (RBD). 155 PD patients including 66 possible RBD (pRBD) and 89 non-possible RBD (npRBD) and 71 normal controls were included. Diffusion-tensor magnetic resonance imaging and graph theory were used to explore the topologic organization of the brain structural connectome. Significant decreased nodal efficiency were found in specific regions including hippocampus and inferior occipital gyrus in PD-pRBD patients. Both these nodal properties were negatively correlated with RBD severity. This study may contribute to understand the pathophysiology of PD-RBD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords