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Abstract #3288

The Structural Connectivity Network of Basal Ganglia in Mouse Brain: MR Diffusion-Tractography at 9.4 T

A-Yoon Kim1 and Hyeon-Man Baek1,2

1Department of Health Science and Technology, GAIHST, Gachon University, gachon university, Incheon, Republic of Korea, Korea, Republic of, 2Lee Gil Ya Cancer and & Diabetes Institute, Gachon university, Incheon, Republic of Korea, Korea, Republic of

Tractography is becoming increasingly common in clinical settings for understanding pathological development and disease, and for assessing pre- and post-operative diagnosis. However, the study on neuronal connectivity network for basal ganglia, a DBS treatment target for Parkinson’s patients, remains unestablished. Therefore, in the present study we have visualized probabilistic diffusion tractography and investigated detailed 3D reconstruction of the projection of basal ganglia structures in mouse model using high-resolution 9.4T MRI. Multi-fiber tractography methods combined with diffusion MRI data have the poential to help identify brain DBS targets in function neurosurgery intervention.

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