Tractography is becoming increasingly common in clinical settings for understanding pathological development and disease, and for assessing pre- and post-operative diagnosis. However, the study on neuronal connectivity network for basal ganglia, a DBS treatment target for Parkinson’s patients, remains unestablished. Therefore, in the present study we have visualized probabilistic diffusion tractography and investigated detailed 3D reconstruction of the projection of basal ganglia structures in mouse model using high-resolution 9.4T MRI. Multi-fiber tractography methods combined with diffusion MRI data have the poential to help identify brain DBS targets in function neurosurgery intervention.
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