Abstract #3289

Altered whole-brain functional networks associated with cognitive dysfunction in end-stage renal disease patients with maintenance hemodialysis

Peng Li^1,2, Xueying Ma³, Dun Ding³, Huawen Zhang¹, Shaohui Ma³, and Ming Zhang³

¹Imgaing department, NO.215 Hospital of Shaanxi Nuclear Industry, Xianyang, China, ²Medical Imaging department, The First Affilicated Hospital of Xi'an Jiaotong University, Xi'an, China, ³Imgaing department, The First Affilicated Hospital of Xi'an Jiaotong University, Xi'an, China

We focused on exploring the whole-brain resting-state functional networks abnormality by using the rs-fMRI with independent component analysis (ICA) algorithm and the relationships with cognitive dysfunction in ESRD patients with hemodialysis. 24 maintenance hemodialysis patients (MHD group) and 26 healthy control subjects (HCs) were evaluated a battery of neuropsychological tests and rs-fMRI scans. Compared with HCs, the MHD group showed worse neuropsychological performances and related decreased functional connectivity in the default mode network, the right frontoparietal network, and the sensorimotor network. Our study might contribute to better understanding underlying neuropathological substrate of cognitive dysfunction in patients with ESRD.

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