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Abstract #3295

Evaluation of white matter integrity in multiple sclerosis using ultra-high gradient diffusion imaging

Fang Frank Yu1, Eric F Klawiter2, and Susie Yi Huang3

1Radiology, UT Southwestern, Dallas, TX, United States, 2Neurology, MASSACHUSETTS GENERAL HOSPITAL, Boston, MA, United States, 3MASSACHUSETTS GENERAL HOSPITAL, Boston, MA, United States

Conventional MRI of multiple sclerosis lacks specificity for the underlying disease-related processes. The use of ultra-high gradient diffusion imaging increases sensitivity for small caliber axons. When used in combination with myelin-sensitive imaging, estimates of axonal volume fraction (AVF), myelin volume fraction (MVF), and the g-ratio can be obtained. Here, we derived estimates of axonal and myelin metrics on a per-voxel basis using ultra-high gradient diffusion MR and macromolecular tissue volume (MTV) in MS patients and healthy controls. Compared to healthy subjects, focal MS lesions and to a lesser extent the normal appearing white matter demonstrated evidence of demyelination and axonal loss.

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