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Abstract #3296

Measuring white matter injury in children with demyelinating syndromes as revealed by non-Gaussian diffusion imaging

Sonya Bells1, Ann E Yeh1,2, and Donald Mabbott1

1Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada, 2Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada

Characterizing whole brain white matter structure in children with demyelinating syndromes (e.g. multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody related disorders (MOG)) may shed light on patterns of injury which are not apparent using conventional imaging techniques. We evaluated group differences in non-Gaussian diffusion data between 26 healthy control, 17 MS and 17 MOG/NMOSD children. We show white-matter microstructure differences between healthy controls and MS patients in areas associated with oculomotor function. Specifically, we show lower axonal density and myelin volume along optic radiations in MS patients than controls or NMOSD/MOG patients.

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