Abstract #3297

Minimum Requirements for Diffusion Tensor Imaging (DTI) for a Longitudinal Trial

Ken E. Sakaie¹, Mark J. Lowe¹, and Robert J. Fox²

¹Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States, ²Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States

This study examines the optimal number of diffusion-weighting gradients for using DTI as an outcome in a multicenter clinical trial. The results suggest that 6 directions may be sufficient for large, simple fiber tracts. This finding may help simplify the implementation of DTI into clinical trials.

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