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Abstract #3300

Tissue microstructure information from T2 relaxometry and diffusion MRI can identify multiple sclerosis (MS) lesions undergoing blood-brain barrier breakdown (BBB)

Sudhanya Chatterjee1, Olivier Commowick1, Onur Afacan2, Simon Keith Warfield2, and Christian Barillot1

1Univ Rennes, Inria, Inserm, CNRS, IRISA UMR 6074, VISAGES - ERL U 1228, F-35000, Rennes, France, 2Computational Radiology Laboratory, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States

Gadolinium based contrast agents (GBCA) play a critical role in identifying MS lesions undergoing BBB which is of high clinical importance. However, repeated use of GBCAs over a long period of time and the risks associated with administering it to patients with renal complications has mandated for greater caution in its usage. In this work we explored the plausibility of identifying MS lesions undergoing BBB from tissue microstructure information obtained from T2 relaxometry and dMRI data. We also proposed a framework to predict MS lesions undergoing BBB using the tissue microstructure information and demonstrated its potential on a test case.

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