Abstract #3301

Myelin measurements using GRASE and mcDESPOT are strongly correlated with those from Multi-Echo Spin-Echo myelin water imaging in postmortem Multiple Sclerosis tissue

Heather Yong^1,2, Irene Vavasour ¹, Cornelia Laule^3,4, Wayne G. Moore⁴, Roger Tam³, Anthony Traboulsee¹, Bruce Trapp⁵, and Shannon Kolind ¹

¹Neurology, University of British Columbia, Vancouver, BC, Canada, ²Medicine, University of Calgary, Calgary, AB, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁵Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleavland, OH, United States

We compared myelin water fraction (MWF) results from the gold standard multi-spin-echo (MSE) sequence to two accelerated techniques: gradient-and-spin-echo (GRASE), and multicomponent-driven equilibrium single pulse observation of T1/T2 (mcDESPOT) in a formalin-fixed multiple sclerosis brain. All three techniques were sensitive to differences in myelin throughout the sample, with MSE and GRASE producing equivalent MWF values. mcDESPOT estimated significantly higher MWF in both normal appearing white matter and lesion compared to MSE and GRASE. However, the MWF was strongly correlated (p<0.0001) between all three methods (r=0.88 for MSE vs. GRASE; r=0.89 for MSE vs. mcDESPOT; r=0.89 for GRASE vs. mcDESPOT).

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