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Abstract #3304

Sodium MRI, SMT, and qMT in Black Holes in Multiple Sclerosis

Ping Wang1,2, Junzhong Xu2,3, Richard Dortch2,3, John C. Gore2,3, and Francesca R. Bagnato4

1Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, UT, United States, 2Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 3Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 4Clinical Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

Black holes in multiple sclerosis (MS) are considered to be more indicative of axonal loss than T2 lesions. We employed three novel MRI techniques, sodium MRI, diffusion MRI via the spherical mean technique, and quantitative magnetization transfer to measure tissue sodium concentration (TSC, for axonal dysfunction), apparent axonal volume fraction (Vax, for axon loss), and macromolecular-to-free pool-size-ratio (PSR, for demyelination degree), respectively. The results showed significant differences of the measures between black holes and the contralateral normal appearing white matters, indicating the potential of using these techniques to provide more specific information on underlying pathology in MS.

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