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Abstract #3305

Quantitative magnetization transfer MRI with improved specificity to demyelinating lesions

Jung-Jiin Hsu1 and Roland G. Henry1

1Department of Neurology, University of California San Francisco, San Francisco, CA, United States

MRI techniques that utilize the magnetization transfer (MT) effect are highly desirable as they potentially can map the myelin content. However, MT measurements produced by conventional MT-MRI techniques, such as MT ratio imaging, vary with the pulse sequence and the scan parameters used. The MT effect and the intrinsic spin–lattice relaxation, both a component of the MR longitudinal relaxation, must be separated to improve MT-MRI accuracy and precision. To solve the problem, a method for MT-MRI is developed in this work. In patients of multiple sclerosis, the present MT-MRI shows improved specificity to demyelinating lesions in the brain.

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