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Abstract #3306

Don’t track edema if you are interested in demyelination: Quantitative susceptibility mapping of MS lesions depends on the image contrast used for lesion definition

Christoph Birkl1,2, Christian Kames1, David Li3, Anthony Traboulsee4, and Alexander Rauscher1,3,5

1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2Department of Neurology, Medical University of Graz, Graz, Austria, 3Department of Radiology, University of British Columbia, Vancouver, BC, Canada, 4Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, 5Department of Pediatrics (Division of Neurology), university of British Columbia, Vancouver, BC, Canada

The purpose of this study was to evaluate how definition of multiple sclerosis lesions affects the measurement of quantitative magnetic susceptibility measurements in these lesions. Masks were drawn on FLAIR and QSM images at baseline and different follow-up time points. QSM was analyzed longitudinally across these lesion masks of the same lesion and compared to NAWM. A strong variability in longitudinal QSM was observed when masks were drawn on FLAIR images. The most consistnt behavior was seen on QSM based masks. The time point of lesion definition had a stronger influence when using FLAIR maks than with QSM based masks.

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