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Abstract #3307

Utilizing QSM to assess long-term longitudinal susceptibility changes in enhancing multiple sclerosis lesions

Shun Zhang1,2, Thanh D. Nguyen2, Sandra Milena Hurtado Rua3, Yi Wang2,4, and Susan A. Gauthier5

1Radiology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China, 2Radiology, Weill Cornell Medical College, New York, NY, United States, 3Mathematics, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, United States, 4Biomedical Engineering, Cornell University, Ithaca, NY, United States, 5Neurology, Weill Cornell Medical College, New York, NY, United States

We measured the longitudinal susceptibility change of 32 new Gd-enhancing lesions from 19 multiple sclerosis (MS) patients over six years. Lesion susceptibility increased to peak within 1-2 years and was followed by a steady decline. Lesions with QSM rim had an overall higher susceptibility and demonstrated a decay rate that was significantly slower compared to that of lesions without rim.

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