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Abstract #3308

Phase imaging and serum neurofilaments: a combined laboratory-imaging marker of multiple sclerosis chronic inflammation

Pietro Maggi1, Martina Absinta2, Amandine Mathias3, Pascal Sati2, Caroline Pot1, Reto Meuli4, Jens Kuhle5, Ludwig Kappos5, Du Pasquier Renaud1, Daniel S. Reich2, and Cristina Granziera5,6

1Department of Neurology, Lausanne University Hospital, Lausanne, Switzerland, 2Translational Neuroradiology Section/NINDS, National Institutes of Health, Bethesda, MD, United States, 3Laboratory of Neuroimmunology, Lausanne University Hospital, Lausanne, Switzerland, 4Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland, 5Department of Neurology, Basel University Hospital, Basel, Switzerland, 6Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engeneering, Basel University Hospital, Basel, Switzerland

In multiple sclerosis (MS), persistent chronic inflammation at the edges of old non-gadolinium-enhancing white matter lesions, is identified with a paramagnetic rim on susceptibility-based-MRI sequences. Serum neurofilaments (sNfL) levels are associated with disease activity and neurodegeneration in acute and chronic phases of MS. Whether the presence of chronic inflammation is accompanied by increased in neuroaxonal destruction is currently unknown. We showed that MS patients featuring chronic inflammation at the lesions edges have higher neuroaxonal destruction than patients without. The combination of paramagnetic rim and sNfL may help in the selection of “chronically” active MS patients who may benefit from disease-modifying-treatments.

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