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Abstract #3309

Multi-Parametric White Matter Imaging in Multiple Sclerosis Lesions

Ewart Mark Haacke1,2,3, Evanthia Bernitsas4, Karthikeyan Subramanian1, David T Utriainen2,3, Vinay Kumar5, Sean Kumar Sethi2,3, Yongsheng Chen1,2, Zahid Latif1, Pavan Kumar1, Xiomeng Zheng6, Robert A Comley6, and Yanping Luo6

1Wayne State University, Detroit, MI, United States, 2The MRI Institute for Biomedical Research, Bingham Farms, MI, United States, 3Magnetic Resonance Innovations Inc., Bingham Farms, MI, United States, 4Multiple Sclerosis Center, Wayne State University School of Medicine, Detroit, MI, United States, 5MR Medical Imaging Innovations Inc., Hyderabad, India, 6AbbVie, North Chicago, IL, United States

A multiparametric quantitative white matter study using MRI was designed to include 15 relapsing remitting MS patients and 10 age and sex matched controls. The imaging protocol acquired 3D conventional imaging, SWI, QSM, DTI, MTC, and STrategically Acquired Gradient Echo (STAGE) imaging. ROI were manually drawn around MS lesions in T2-FLAIR and QSM. Contralateral normal appearing white matter (NAWM) and NAWM in controls were drawn in all modalities to measure mean intensity and volume. We found a good correlation between QSM, MTR, FA, MWF and conventional imaging. QSM’s sensitivity to demyelination best complimented T2-FLAIR’s sensitivity to inflammation and scarring.

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