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Abstract #3310

Phase opposed cerebral vasoreactivity in multiple sclerosis: evidences of a link between white matter tracts and vascular alterations

Jeremy Deverdun1, Arthur Coget2, Victor Vagné3, Amel Benali1, Pierre Labauge4, Nicolas Menjot de Champfleur1,2, and Emmanuelle Le Bars1

1I2FH, Institut d’Imagerie Fonctionnelle Humaine, Gui de Chauliac Hospital, Montpellier, France, Montpellier, France, 2Department of Neuroradiology, University Hospital Center, Gui de Chauliac Hospital, France, Montpellier, France, 3LIRMM, Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier, France, Montpellier, France, 4Department of Neurology, CHU de Montpellier, Montpellier, France, montpellier, France

Patients with multiple sclerosis (MS) have a higher risk for ischaemic stroke. The current hypothesis states that white matter (WM) fibers alterations causes, through astrocytes, a cerebral vasoreactivity (CVR) disruption resulting in a hypoperfusion. Due to the location of the astrocytes, we expect an altered vasoreactivity mainly around WM tracts. Using a MR vasoreactivity experiment, we could identify altered WM pathways. In MS patients a path from left anterior insula to both precentral gyrus and right middle and superior frontal gyrus highlighted an altered CVR compared to controls. A negative association was found with fNART in the cingulum limbic pathway.

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