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Abstract #3317

Measurement of cerebral perfusion changes during breath holding using pCASL with an accelerated 3D readout: an approach to quantify cerebrovascular reactivity.

Sergio M. Solís-Barquero1, Rebeca Echeverria1, Elena Cacho-Asenjo2, Antonio Martínez-Simón2, Marta Vidorreta3, Pablo Domínguez1, Miguel Fernández1, and María A. Fernández-Seara1

1Radiology, Clínica Universidad de Navarra, Pamplona, Spain, 2Anesthesia, Perioperative Medicine and Critical Care, Clínica Universidad de Navarra, Pamplona, Spain, 3Siemens Healthineers, Madrid, Spain

Cerebrovascular reactivity (CVR) can be defined as the change in flow in response to a vasoactive agent. Hypercapnia is known to cause global increases in cerebral blood flow (CBF). ASL can provide a quantitative measure of CBF changes. The objective of this research was to determine whether pseudo-continuous ASL (pCASL) with an accelerated 3D readout, combined with breath-hold induced hypercapnia, is a practicable method for evaluating CVR. Results showed that the faster readout provided whole-brain coverage at isotropic resolution and allowed a post-labeling delay long enough to avoid macrovascular signal artifacts, while keeping TR short to sample several points per breath-hold.

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