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Abstract #3318

Tractography of complex white matter bundles: limitations of diffusion MRI data upsampling

Dmitri Shastin1, Umesh Rudrapatna2, Greg Parker2, Khalid Hamandi1, William P. Gray1, Derek K. Jones2, and Maxime Chamberland2

1Cardiff University Brain Research Imaging Centre (CUBRIC), Division of Clinical Neurosciences and Psychological Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom

Diffusion MRI images for fiber tractography are often acquired at low spatial resolution which may lead to underestimation of smaller tracts with complex morphology. Although upsampling may improve results, this has had mixed observations in the literature. We compared three datasets (2×2×2 mm3, 1.5×1.5×1.5 mm3, and 2×2×2 mm3 upsampled to 1.5×1.5×1.5 mm3) obtained and processed using state-of-the-art hardware and methodology. By evaluating the appearances and streamline metrics of the corticospinal tract, anterior commissure and small subcortical U-shaped fibers as test bundles, we demonstrated that the original high-resolution dataset outperformed both the low-resolution and upsampled data in resolving complex regional anatomy.

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