This study assesses the repeatability of image quality of inhaled
hyperpolarized 129Xe brain MRI by assessing the signal-to-noise
ratio of 129Xe brain images for five healthy subjects. A maximum signal-to-noise ratio of 18.8 ±6.1
and mean signal-to-noise ratio of 12.1 ±3.8 was observed over the five
volunteers. An intra-subject variability between ±6 % and ±30 %, and inter-subject
variability of ±30 % was observed. By using an optimized polarizer, RF coil and
pulse sequence as in this study, we believe the signal-to-noise ratio is sufficiently
reproducible for further clinical evaluation.