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Abstract #3319

Assessment of repeatability of imaging inhaled hyperpolarized xenon-129 in the human brain

Madhwesha Rao1, Graham Norquay1, and Jim Wild1

1University Of Sheffield, Sheffield, United Kingdom

This study assesses the repeatability of image quality of inhaled hyperpolarized 129Xe brain MRI by assessing the signal-to-noise ratio of 129Xe brain images for five healthy subjects. A maximum signal-to-noise ratio of 18.8 ±6.1 and mean signal-to-noise ratio of 12.1 ±3.8 was observed over the five volunteers. An intra-subject variability between ±6 % and ±30 %, and inter-subject variability of ±30 % was observed. By using an optimized polarizer, RF coil and pulse sequence as in this study, we believe the signal-to-noise ratio is sufficiently reproducible for further clinical evaluation.

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