Abstract #3325

Longitudinal brain volume changes in pre-menopausal breast cancer patients treated with chemotherapy

Gwen Schroyen¹, Jeroen Blommaert², Mathieu Vandenbulcke^3,4, Ahmed Radwan¹, Ann Smeets^2,5, Ron Peeters^1,6, Charlotte Sleurs², Patrick Neven^2,7, Hans Wildiers^2,8, Frederic Amant^2,7,9, Stefan Sunaert^1,6, and Sabine Deprez¹

¹Imaging and Pathology, KU Leuven, Leuven, Belgium, ²Oncology, KU Leuven, Leuven, Belgium, ³Neurosciences, KU Leuven, Leuven, Belgium, ⁴Psychiatry, KU Leuven, Leuven, Belgium, ⁵Surgical Oncology, KU Leuven, Leuven, Belgium, ⁶Radiology, KU Leuven, Leuven, Belgium, ⁷Gynaecology and Obstetrics, KU Leuven, Leuven, Belgium, ⁸General Medical Oncology, KU Leuven, Leuven, Belgium, ⁹Center for Gynaecologic Oncology, Anthoni van Leeuwenhoek, Netherlands Cancer Insitute, Academical Medical Center, Amsterdam, Netherlands

This longitudinal study investigates possible recovery of volumetric brain changes in pre-menopausal patients three years after being treated for early-stage breast cancer. While initial widespread white matter volume increase was previously observed, recovery is seen three years after treatment in the same group of young women treated with chemotherapy. Patients with breast cancer show widespread gray matter volume decrease, observed both in patients treated and not treated with cytotoxic agents. Further studies are necessary to unravel possible acute volumetric changes, possibly neuro-inflammatory mechanisms, in this population as a cause for these findings.

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