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Abstract #3325

Longitudinal brain volume changes in pre-menopausal breast cancer patients treated with chemotherapy

Gwen Schroyen1, Jeroen Blommaert2, Mathieu Vandenbulcke3,4, Ahmed Radwan1, Ann Smeets2,5, Ron Peeters1,6, Charlotte Sleurs2, Patrick Neven2,7, Hans Wildiers2,8, Frederic Amant2,7,9, Stefan Sunaert1,6, and Sabine Deprez1

1Imaging and Pathology, KU Leuven, Leuven, Belgium, 2Oncology, KU Leuven, Leuven, Belgium, 3Neurosciences, KU Leuven, Leuven, Belgium, 4Psychiatry, KU Leuven, Leuven, Belgium, 5Surgical Oncology, KU Leuven, Leuven, Belgium, 6Radiology, KU Leuven, Leuven, Belgium, 7Gynaecology and Obstetrics, KU Leuven, Leuven, Belgium, 8General Medical Oncology, KU Leuven, Leuven, Belgium, 9Center for Gynaecologic Oncology, Anthoni van Leeuwenhoek, Netherlands Cancer Insitute, Academical Medical Center, Amsterdam, Netherlands

This longitudinal study investigates possible recovery of volumetric brain changes in pre-menopausal patients three years after being treated for early-stage breast cancer. While initial widespread white matter volume increase was previously observed, recovery is seen three years after treatment in the same group of young women treated with chemotherapy. Patients with breast cancer show widespread gray matter volume decrease, observed both in patients treated and not treated with cytotoxic agents. Further studies are necessary to unravel possible acute volumetric changes, possibly neuro-inflammatory mechanisms, in this population as a cause for these findings.

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