We implemented a first order gradient nulling (GMN) based partial flow compensation in 3D interleaved EPI and assessed its feasibility for a fast high-resolution SWI application at 1.5T. Specifically, we used GMN to zero the velocity-induced phase error at the center echo for each shot in both phase and frequency encoding directions. The slice direction implementation was identical to that for 3D GRE, with flow compensation for both slice selective gradient and partition encoding gradient. In addition, each shot was sequentially acquired twice with the swapped readout polarity in the second to further reduce the phase oscillates between the even and odd echoes in each shot. Flow phantom and in-vivo experiments were performed to validate that flow effect is effectively reduced even not all echoes have been fully flow compensated.