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Abstract #3333

Investigating the biodistribution of the antiinflammatory drug teriflunomide in vivo using 19F MRI

Christian Prinz1, Jason Michael Millward1, Paula Ramos Delgado1, Ludger Starke1, Andreas Pohlmann1, Thoralf Niendorf1,2, and Sonia Waiczies1

1Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany, 2Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany

Teriflunomide is a trifluorinated drug indicated in the treatment of multiple sclerosis (MS). Using fluorine (19F) MR methods, the biodistribution of this anti-inflammatory drug could be examined in vivo to guide pharmacological studies and dosage adjustments en route to individualized therapy. In this study, we administered teriflunomide to healthy rats and an animal model of MS. We could detect teriflunomide non-invasively in various tissues in vivo, during the disease course and ex vivo.

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