Abstract #3333

Investigating the biodistribution of the antiinflammatory drug teriflunomide in vivo using 19F MRI

Christian Prinz¹, Jason Michael Millward¹, Paula Ramos Delgado¹, Ludger Starke¹, Andreas Pohlmann¹, Thoralf Niendorf^1,2, and Sonia Waiczies¹

¹Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany, ²Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany

Teriflunomide is a trifluorinated drug indicated in the treatment of multiple sclerosis (MS). Using fluorine (¹⁹F) MR methods, the biodistribution of this anti-inflammatory drug could be examined in vivo to guide pharmacological studies and dosage adjustments en route to individualized therapy. In this study, we administered teriflunomide to healthy rats and an animal model of MS. We could detect teriflunomide non-invasively in various tissues in vivo, during the disease course and ex vivo.

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