The central vein sign is well documented as a biomarker for multiple sclerosis at high-resolution MRI. To investigate its potential at lower resolution and inform clinical MR protocol parameters, interpolation was used to demonstrate the effect of decreasing the resolution in 30 MS patients who underwent 7T-MRI. Finding were compared to 5 Non-MS groups (n = 82) at different resolutions using logistic regression. At half the original resolution the proportion of perivenular lesions changed considerably (73% to 47%), however, classification results remained unaffected provided the threshold (proportion of perivenular lesions) used for the differentiation decreased at lower resolution.
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