Abstract #3337

Development of High Quality T1w and DTI Templates of the Older Adult Brain in a Common Space

Yingjuan Wu¹, Abdur Raquib Ridwan¹, Xiaoxiao Qi¹, Shengwei Zhang¹, David A. Bennett², and Konstantinos Arfanakis^1,2

¹Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University, Chicago, IL, United States

The demand for a multimodal MRI atlas of the older adult brain is increasing as large amounts of data are generated in studies of aging. The purpose of this work was to develop high quality T1-weighted (T1w) and diffusion tensor imaging (DTI) templates of the older adult brain in the same space, to allow future multimodal analyses. This was successfully accomplished through a proposed iterative multimodal template construction strategy. The new templates allowed higher spatial normalization accuracy of T1w and DTI data from older adults compared to other available templates.

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