Abstract #3338

Diffusion imaging of rat brain slices on a human clinical MRI scanner

Natalie Aw^1,2, Alex Cerjanic^2,3, Jennifer Mitchell^2,4, Martha Gillette^2,4, and Brad Sutton^1,2,3

¹Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ²Beckman Institute for Advanced Science and Technology, Urbana, IL, United States, ³Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁴Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, United States

We demonstrate the feasibility of performing diffusion tensor imaging on a rat brain slice using a 3 T human clinical scanner and a rat coil. Brain slices provide an important platform for performing mechanistic studies in neuroscience. We show that sufficient SNR is available for performing experiments to examine the diffusion properties of white matter through examining age-related differences in FA on 8-week-old and 1-year-old rats.

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