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Abstract #3338

Diffusion imaging of rat brain slices on a human clinical MRI scanner

Natalie Aw1,2, Alex Cerjanic2,3, Jennifer Mitchell2,4, Martha Gillette2,4, and Brad Sutton1,2,3

1Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, Urbana, IL, United States, 3Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, 4Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, United States

We demonstrate the feasibility of performing diffusion tensor imaging on a rat brain slice using a 3 T human clinical scanner and a rat coil. Brain slices provide an important platform for performing mechanistic studies in neuroscience. We show that sufficient SNR is available for performing experiments to examine the diffusion properties of white matter through examining age-related differences in FA on 8-week-old and 1-year-old rats.

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