Abstract #3373

Structural anatomy of the executive control network – a high angular resolution diffusion MRI study

Kaikai Shen^1,2,3, Thomas Welton³, Matt Lyon³, Jurgen Fripp¹, Ralph Martins², and Stuart M Grieve^3,4

¹Australian eHealth Research Centre, CSIRO, Brisbane, Australia, ²Department of Biomedical Sciences, Macquarie University, Sydney, Australia, ³Sydney Translational Imaging Laboratory, Heart Research Institute, University of Sydney, Sydney, Australia, ⁴Department of Radiology, Royal Prince Alfred Hospital, Sydney, Australia

In this abstract, our aim is to investigate the relationship between executive function and the underlying structures of the executive control network (ECN) in the normal population. To this end, we acquired multi-shell diffusion MRI data with 391 gradient directions to estimate the structural connectivity within this functionally-defined network, and evaluated the executive function of the subjects. We used network-based statistic (NBS) to assess the relationships between executive function and the ECN connectivity, and found that the structural connectivity between hemispheres displayed positive correlation with higher executive function performance, while the connectivity within a sub-network in the right hemisphere showed a negative correlation with executive function.

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