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Abstract #3391

Diffusion Gradient Nonlinearity Correction in a Diffusion Phantom and in Breast Cancer Bone Metastases

Thomas Winther Buus1, Anders Bonde Jensen2, and Erik Morre Pedersen1

1Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, 2Department of Oncology, Aarhus University Hospital, Aarhus, Denmark

The purpose was to investigate if diffusion gradient nonlinearity (DGNL) ADC-errors could be corrected in vitro and in vivo.


DWIBS was performed in a diffusion phantom and in breast cancer patients. ADC-maps with and without DGNL correction were created and compared at different positions relative to the isocenter.


In the diffusion phantom uncorrected ADC-values 17.5cm from the isocenter dropped by 29-32% while the corrected ADC-values increased by 2-4%.

In 85 bone metastases uncorrected ADC-values 14cm from the isocenter dropped by 18.7% while corrected ADC-values dropped by 2.8%.


DGNL ADC-errors can be corrected in vitro and in vivo.

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