The purpose was to investigate if diffusion gradient nonlinearity (DGNL) ADC-errors could be corrected in vitro and in vivo.
DWIBS was performed in a diffusion phantom and in breast cancer patients. ADC-maps with and without DGNL correction were created and compared at different positions relative to the isocenter.
In the diffusion phantom uncorrected ADC-values 17.5cm from the isocenter dropped by 29-32% while the corrected ADC-values increased by 2-4%.
In 85 bone metastases uncorrected ADC-values 14cm from the isocenter dropped by 18.7% while corrected ADC-values dropped by 2.8%.
DGNL ADC-errors can be corrected in vitro and in vivo.