Abstract #3420

Measuring white matter damage in different types of MS

Chunyu Song¹, Peng Sun², Anne H. Cross³, Zezhong Ye⁴, and Sheng-Kwei (Victor) Song⁵

¹Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States, University City, MO, United States, ²Radiology, Washington University School of Medicine, St. Louis, MO, United States, University City, MO, United States, ³Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States, Saint Louis, MO, United States, ⁴Chemistry, Washington University in St. Louis, st louis, MO, United States, ⁵Radiology, Washington University School of Medicine, St. Louis, MO, United States, Saint Louis, MO, United States

A new diffusion histology imaging (DHI) is proposed to model intra and extra axonal diffusion along with isotropic diffusion within an image voxel of diffusion-weighted MR images. It resolves crossing fibers while more accurately detecting and quantifying axonal injury, axon loss, demyelination, edema and inflammation. Through the multiple-tensor modelling of diffusion-weighted MRI signals, DHI has shown the potential to detect underlying pathologies of normal appearing corpus callosum in all clinical subtypes of multiple sclerosis.

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