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Abstract #3421

Evaluating Neurite Density and Orientation in the White Matter of Youth Born with Congenital Heart Disease

Kaitlyn Easson1, Jean-Christophe Houde2, Guillaume Gilbert3, Kimberly Fontes1, Charles Rohlicek4, Christine Saint-Martin5, Annette Majnemer6, Maxime Descoteaux2, and Marie Brossard-Racine1

1Advances in Brain & Child Development Research Laboratory, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Sherbrooke Connectivity Imaging Lab, Université de Sherbrooke, Sherbrooke, QC, Canada, 3MR Clinical Science, Philips Healthcare, Markham, ON, Canada, 4Division of Cardiology, Montreal Children's Hospital, Montreal, QC, Canada, 5Division of Radiology, Montreal Children's Hospital, Montreal, QC, Canada, 6School of Physical & Occupational Therapy, McGill University, Montreal, QC, Canada

In this study, neurite orientation dispersion and density imaging (NODDI) was used to quantify neurite density and orientation in white matter tracts in youth born with congenital heart disease (CHD). Neurite density index was significantly lower in youth born with CHD as compared to control youth in numerous, widespread association tracts. There were no regional differences in orientation dispersion index that survived correction for multiple comparisons. Our findings suggest a predominant role for lower neurite density, rather than lower neurite coherence and organization, in the white matter abnormalities observed in youth born with CHD.

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