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Abstract #3425

Reproducibility of the diffusion of the perivascular space in older adults with dementia.

Christopher Steward1, Vijay Venkatraman1, Elaine Lui2, Charles Malpas1, Kathyrn Ellis1, Terence O'Brien1, Nicola Lautenschlager1, and Patricia Desmond1

1University of Melbourne, Melbourne, Australia, 2Royal Melbourne Hospital, Melbourne, Australia

Recently, there has been interest in the glymphatic system and its role in flushing amyloid ß along with other waste products in the brain. New imaging techniques are being developed to try and measure such activity. Recently, diffusion tensor MRI was used to construct an index "DTI-ALPS" to help link dementia burden with diffusion in the perivascular space. We aimed to replicate this study in 36 patients (16 AD, 16 MCI, and 4 SMC). Significant correlations were found between DTI-ALPS and stratified Mini-Mental State Examination score. Further work is needed to evaluate the feasibility of MRI to measure glymphatic activity.

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