Abstract #3426

Multivariate characterization of brain white matter maturation related to intellectual ability in children

Yannan Cheng¹, Chao Jin², Xianjun Li², Congcong Liu², Miaomiao Wang², Xiaocheng Wei³, Yuli Zhang², Fan Wu², Mengxuan Li², and Jian Yang²

¹Department of Radiology, the First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, Xi’an, China, ²the First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, Xi'an, China, ³MR Research China, GE Healthcare, Bei Jing, People's Republic of China, Bei Jing, China

Brain maturations are thought to relate to behavioral acquisitions and cognitive development. Nevertheless, in vivo investigations of such relationships remain scarce in childhood. To bridge this gap, a multivariate index (D_M), which delineates the “maturational distance” between children and adults and leverages DTI-metrics complementarity, was utilized to characterize WM variation. We found that D_M showed significantly negative correlations with FSIQ in children aged 4-12 yr, especially in cingulum and superior longitudinal fasciculus. Besides, left hemispheric lateralization (higher correlations with FSIQ) was also observed. Our findings suggest D_M as a useful biomarker in detailing the brain WM maturation related to intelligence.

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