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Abstract #3426

Multivariate characterization of brain white matter maturation related to intellectual ability in children

Yannan Cheng1, Chao Jin2, Xianjun Li2, Congcong Liu2, Miaomiao Wang2, Xiaocheng Wei3, Yuli Zhang2, Fan Wu2, Mengxuan Li2, and Jian Yang2

1Department of Radiology, the First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, Xi’an, China, 2the First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, Xi'an, China, 3MR Research China, GE Healthcare, Bei Jing, People's Republic of China, Bei Jing, China

Brain maturations are thought to relate to behavioral acquisitions and cognitive development. Nevertheless, in vivo investigations of such relationships remain scarce in childhood. To bridge this gap, a multivariate index (DM), which delineates the “maturational distance” between children and adults and leverages DTI-metrics complementarity, was utilized to characterize WM variation. We found that DM showed significantly negative correlations with FSIQ in children aged 4-12 yr, especially in cingulum and superior longitudinal fasciculus. Besides, left hemispheric lateralization (higher correlations with FSIQ) was also observed. Our findings suggest DM as a useful biomarker in detailing the brain WM maturation related to intelligence.

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