Abstract #3431

Diffusion MRI detects changes in the Hippocampus and Fimbria-Fornix Circuit in 2 months old 3xTg-AD mice

Maria Fatima Falangola^1,2, Xingju Nie^1,2, Emilie T. McKinnon^1,2,3, Joseph A. Helpern^1,2,3,4, and Jens H. Jensen^1,2,4

¹Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States, ²Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States, ³Department of Neurology, Medical University of South Carolina, Charleston, SC, United States, ⁴Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States

The triple transgenic mouse model (3xTg) of Alzheimer’s disease (AD) exhibits both Aβ and tau pathology. Interestingly, the first detectable pathological features in this model are alterations in overall myelination patterns leading to white matte disruption as early as 2 months of age. Here we investigated the sensitivity of diffusion MRI (dMRI) to detect brain changes in young 3xTg mice. Our results indicate that dMRI is able to capture brain microstructural alterations associated with the hippocampus-fimbria-fornix circuit in 2 months-old 3xTg-AD mice, thus demonstrating dMRI as a viable tool for studying abnormal pathology in this AD mouse model.

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