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Abstract #3432

3D Diffusion MRI of Perivascular Fluid Movement: Towards Non-Invasive Mapping of Glymphatic Function.

Phoebe Evans1, Bernard Siow1,2, Ian Harrison1, Ozama Ismail1, Yolanda Ohene1, Payam Nahavandi 1, David Thomas3,4, Mark Lythgoe1, and Jack Wells1

1Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, 2The Francis Crick Institute, London, United Kingdom, 3Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom, 4Leonard Wolfson Experimental Neurology Centre, UCL Queen Square Institute of Neurology, London, United Kingdom

Within the glymphatic system, CSF is transported in a network of perivascular channels where it exchanges with ISF to drive drainage of unwanted solutes, like amyloid- β, out of the brain. Perivascular channel impairment may be an early biomarker of neurodegenerative processes. Here, we present a pilot study for 3D non-invasive assessment of glymphatic function in the rat brain using ultra-long echo time diffusion MRI. We show that this technique is sensitive to the fluid movement in downstream perivascular channels that drives glymphatic inflow.

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