Abstract #3432

3D Diffusion MRI of Perivascular Fluid Movement: Towards Non-Invasive Mapping of Glymphatic Function.

Phoebe Evans¹, Bernard Siow^1,2, Ian Harrison¹, Ozama Ismail¹, Yolanda Ohene¹, Payam Nahavandi ¹, David Thomas^3,4, Mark Lythgoe¹, and Jack Wells¹

¹Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, ²The Francis Crick Institute, London, United Kingdom, ³Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁴Leonard Wolfson Experimental Neurology Centre, UCL Queen Square Institute of Neurology, London, United Kingdom

Within the glymphatic system, CSF is transported in a network of perivascular channels where it exchanges with ISF to drive drainage of unwanted solutes, like amyloid- β, out of the brain. Perivascular channel impairment may be an early biomarker of neurodegenerative processes. Here, we present a pilot study for 3D non-invasive assessment of glymphatic function in the rat brain using ultra-long echo time diffusion MRI. We show that this technique is sensitive to the fluid movement in downstream perivascular channels that drives glymphatic inflow.

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