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Abstract #3434

Functional and microstructural alterations in the rat hippocampus after repetitive mild traumatic brain injury

Ahmad Raza Khan1, Brian Hansen1, Nina K Iversen1, Jonas Lynge Olesen1,2, Mariana Angoa Perez3, Donald M .Kuhn3, and Sune N Jespersen1,2

1Clinical Medicine, Aarhus University, Ã…rhus C, Denmark, 2Department of Physics and Astronomy, Aarhus University, Aarhus C, Denmark, 3John D. Dingell VA Medical Center, Wayne State University, Detroit, MI, United States

Repetitive mild traumatic brain injury (mTBI) causes subtle tissue injury, which often reports normal under CT and MRI, leading to suboptimal diagnosis and increase the risk of developing neurological disorders. We probe microstructural alterations using advanced diffusion MRI, and perfusion MRI based cerebral blood flow (CBF) in rats before and after repetitive mTBI. Mean diffusivity and radial kurtosis tensor (WT) indicate the microstructural alteration in the ipsilateral hippocampus (IHP) and ipsilateral corpus callosum (ICC) respectively, and CBF maps show a significant reduction in the IHP. Our study suggests that multimodal imaging can provide useful information for early diagnosis of repetitive mTBI.

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