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Abstract #3440

DTI of Spinal Cord Lesions of Varying Severity Based on MRI in the Entire Pediatric Spinal Cord

SONA SAKSENA1, Feroze B Mohamed1, Devon M Middleton1, Laura Krisa1, Mahdi M Alizadeh1, Shiva Shahrampour1, Chris C Conklin1, Adam Flanders1, J├╝rgen Finsterbusch2, MJ Mulcahey1, and Scott H Faro3

1Thomas Jefferson University, Philadelphia, PA, United States, 2University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3Johns Hopkins School of Medicine, Baltimore, MD, United States

To determine whether DTI at sites cephalad and caudal to the MRI lesion provides measures of cord abnormalities in different SCI groups (n=23) compared to TD (n=36) and any correlation between the varying severity of MRI abnormality and DTI abnormalities cephalad and caudal to the MRI lesion. to the MRI lesion. The five SCI groups included; 1= SCIWORA (n=6); 2=Syringohydromyelia (n=4); 3=Atrophy+Syringomyelia (n=7); 4=Atrophy+Myelomalacia (n=3); 5=Atrophy+Hemorrhage (n=3). Groups 1 to 5 represent a progressive measure in cord abnormality. Among these SCI groups, we looked at concordant DTI correlation which is defined as the expected change in DTI metrics with increasing cord severity. SCIWORA showed DTI abnormality at segments of the cephalad and caudal cord with the caudal cord more affected consistent with the anterograde degeneration. FA showed the greatest total number of segments in the cephalad and caudal cord that showed abnormal DTI values in comparison to the other DTI metrics.

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