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Abstract #3439

Correlation between IVIM parameters and cT1 in HCV patients

Michele Nicastro1, Nicola Martini2, Matteo Milanesi3, Chloe Hutton3, Antonio Salvati4, Daniele Della Latta2, Maurizia R. Brunetto4,5, Matthew Robson3, Luigi Landini2,6, and Dante Chiappino2

1Dept of Physics, Vision Lab, University of Antwerp, Antwerp, Belgium, 2Fondazione Toscana "G.Monasterio", Massa, Italy, 3Perspectum Diagnostics, Oxford, United Kingdom, 4Hepatology Unit, University Hospital of Pisa, Pisa, Italy, 5Dept Clinical and Experimental Medicine, University Of Pisa, Pisa, Italy, 6Dept of Information Engineering, University Of Pisa, Pisa, Italy

IVIM imaging has been investigated by several researchers to understand its clinical potential. However, the dependency from b-value distribution and the effect of confounding factors such as iron and steatosis make hard to draw conclusion. In this work, a multiparametric protocol was proposed to address those confounds and the correlation with iron-corrected T1 (cT1) was studied in a group of patients affected by hepatitis C. The vascular volume fraction F shows a statistically relevant correlation with cT1 (p<0.001).

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