Abstract #3439

Correlation between IVIM parameters and cT1 in HCV patients

Michele Nicastro¹, Nicola Martini², Matteo Milanesi³, Chloe Hutton³, Antonio Salvati⁴, Daniele Della Latta², Maurizia R. Brunetto^4,5, Matthew Robson³, Luigi Landini^2,6, and Dante Chiappino²

¹Dept of Physics, Vision Lab, University of Antwerp, Antwerp, Belgium, ²Fondazione Toscana "G.Monasterio", Massa, Italy, ³Perspectum Diagnostics, Oxford, United Kingdom, ⁴Hepatology Unit, University Hospital of Pisa, Pisa, Italy, ⁵Dept Clinical and Experimental Medicine, University Of Pisa, Pisa, Italy, ⁶Dept of Information Engineering, University Of Pisa, Pisa, Italy

IVIM imaging has been investigated by several researchers to understand its clinical potential. However, the dependency from b-value distribution and the effect of confounding factors such as iron and steatosis make hard to draw conclusion. In this work, a multiparametric protocol was proposed to address those confounds and the correlation with iron-corrected T1 (cT1) was studied in a group of patients affected by hepatitis C. The vascular volume fraction F shows a statistically relevant correlation with cT1 (p<0.001).

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