IVIM model and DKI model cover different aspects of diffusion, thus a combined IVIM-DKI model might describe diffusion in perfused biological tissues more accurately. The aim of the study was to quantitatively compare the potential of various parameters obtained from IVIM model, Kurtosis model and IVIM-Kurtosis model in the grading of hepatocellular carcinoma (HCC). We enrolled 24 HCC patients who underwent multiple b values Diffusion-Weighted Imaging (DWI) with subsequent pathological confirmation. Our results showed that all three models could differentiate high-grade HCC from low-grade HCC and IVIM-Kurtosis model may be superior to IVIM model.
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