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Abstract #3445

Increasing reader confidence in cancer imaging using an advanced DWI processing – a prospective reader study

Constantin Dreher1, Tristan Anselm Kuder2, Stefan Windhaber1, Franziska König1, Daniel Paech1, Anoshirwan Tavakoli1, Regula Gnirs1, Thomas Benkert3, Heinz-Peter Schlemmer1, and Sebastian Bickelhaupt1

1Radiology, German Cancer Research Center, Heidelberg, Germany, 2Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 3Siemens Healthcare GmbH, Erlangen, Germany

Diffusion-Weighted imaging (DWI) in abdominal MRI is highly valuable for oncological follow-up-investigations. However, intrinsic limitations of the method, including susceptibility to motion artifacts and poor signal in the retroperitoneum, are of special importance regarding its usage in abdominal examinations. This prospective study compared a standard EPI-DWI with an oncologically optimized prototype DWI in 59 patients with regard to the detectability/characterization of suspicious lesions. The study demonstrated that the oncologically optimized prototype DWI sequence with complex averaging, motion correction between averages, rescaling of motion corrupted averages, and background suppression, significantly increased the reader confidence for lesion characterization/detection in oncological abdominal MRI.

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